Acute Tubular Necrosis Is a Syndrome of Physiologic and Pathologic Dissociation

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Acute tubular necrosis is a syndrome of physiologic and pathologic dissociation.

Acute tubular necrosis (ATN) is a syndrome of intrinsic renal failure secondary to ischemic or toxic insults. The histopathologic findings of ATN are inconstant. When present, they are limited to the tubulo-interstitium and often subtle despite profound dysfunction. Experimental models of ATN in healthy animals commonly use single insults that result in extensive injury, circumstances that do n...

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Reye's syndrome associated with acute tubular necrosis.

Two cases of Reye's syndrome, complicated by acute reversible renal failure, are presented. One case followed an influenza A virus infection.

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Acute Tubular Necrosis

A rapid rise in creatinine following periods of hypotension is most commonly due to acute tubular necrosis. In ATN, urinalysis usually shows granular casts. Urine sodium is typically high due to tubular sodium loss, concentration is typically above 30 mmol/l. The urine to plasma osmolality ratio <1:1, the ability to concentrate urine is preserved despite sodium loss. Acute Tubular Necrosis is a...

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Acute Tubular Necrosis and Dengue

The recent article on “acute tubular necrosis and dengue” is very interesting. REPIZO et al. concluded that “serum creatine phosphokinase should be monitored in DF patients to allow for an early diagnosis of rhabdomyolysis and the institution of renal protective measures”. In fact, the renal complication of dengue is not rare and it should be kept in mind for all practitioners. The renal proble...

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Vancomycin-induced acute tubular necrosis.

OBJECTIVES To report nephrotoxicity in the form of acute tubular necrosis (ATN) related to vancomycin. METHODS This study was conducted at Johns Hopkins Aramco Healthcare, Saudi Aramco, Dharan, Saudi Arabia between June and August 2013. All patients who received intravenous vancomycin as a part of the hospital's vancomycin stewardship program were monitored for the development of ATN. RESUL...

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ژورنال

عنوان ژورنال: Journal of the American Society of Nephrology

سال: 2008

ISSN: 1046-6673,1533-3450

DOI: 10.1681/asn.2007080913